Gamma-hydroxybutyrate for sedation in children

Acute Gamma Hydroxybutyrate Toxicity

Gamma-hydroxybutyrate / Butyric Acid

Gamma-hydroxybutyrate / butyric acid, ambiguously called GHB, presents some unique challenges for analysis due in part to its acidity, high polarity, and high solubility in aqueous solution. Its chemistry is complicated by its conversion into the corresponding lactone compound, where the GHB molecule condenses to form a cyclic ester with a five-membered ring. This compound, gamma-butyrolactone ...

Gamma-Hydroxybutyrate (GHB) Withdrawal

Gamma-hydroxybutyrate, gamma-butyrolactone, and 1,4-butanediol.

1 National Poisons Centre, Department of Preventive and Social Medicine, University of Otago, Dunedin, New Zealand 2 Department of Anesthesia and Intensive Care Medicine, Surgical Sciences, Blå Stråket 5, Sahlgrenska University Hospital, Gothenburg, Sweden 3 National Poisons Information Service (Birmingham Unit) and West Midlands Poisons Unit, City Hospital, Birmingham, UK; School of Bioscience...

Baclofen and gamma-hydroxybutyrate withdrawal.

INTRODUCTION Benzodiazepine treatment of life-threatening gamma-hydroxybutyrate (GHB) withdrawal is frequently unsatisfactory. Animal studies suggest strongly that treatment with GABA(B) agonists, such as baclofen, will be a more effective strategy. METHODS A case report from the medical intensive care unit (ICU) of the university tertiary care hospital. RESULTS A 61-year-old woman was admi...